|
gptkbp:instanceOf
|
sulfonylurea
antidiabetic drug
|
|
gptkbp:approvalYear
|
1995
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
A10BB12
|
|
gptkbp:brand
|
gptkb:Amaryl
|
|
gptkbp:CASNumber
|
93479-97-1
|
|
gptkbp:color
|
white to yellowish-white powder
|
|
gptkbp:contraindication
|
gptkb:diabetic_ketoacidosis
type 1 diabetes
|
|
gptkbp:discoveredBy
|
gptkb:Hoechst_AG
|
|
gptkbp:drugInteraction
|
gptkb:beer
gptkb:insulin
gptkb:NSAIDs
beta blockers
|
|
gptkbp:eliminationHalfLife
|
5-8 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:hasMolecularFormula
|
C24H34N4O5S
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
glimepiride
|
|
gptkbp:KEGGID
|
D00564
|
|
gptkbp:legalStatus
|
prescription only
off-patent
|
|
gptkbp:mechanismOfAction
|
stimulates insulin release from pancreatic beta cells
|
|
gptkbp:meltingPoint
|
207-209°C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:origin
|
synthetic
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:proteinBinding
|
>99%
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1431
3476
3356
DB00222
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gptkb:hypoglycemia
nausea
weight gain
allergic skin reactions
|
|
gptkbp:solubility
|
practically insoluble in water
|
|
gptkbp:synonym
|
gptkb:Glimide
gptkb:Glymepiride
|
|
gptkbp:UNII
|
X9SS35U5EM
|
|
gptkbp:usedFor
|
gptkb:type_2_diabetes_mellitus
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
included
|
|
gptkbp:bfsParent
|
gptkb:Amaryl
|
|
gptkbp:bfsLayer
|
6
|