|
gptkbp:instanceOf
|
gptkb:drug
loop diuretic
|
|
gptkbp:alternativeName
|
furosemide
|
|
gptkbp:ATCCode
|
C03CA01
|
|
gptkbp:bioavailability
|
60% (oral)
|
|
gptkbp:brand
|
Lasix
Frusid
Fursemide
|
|
gptkbp:CASNumber
|
54-31-9
|
|
gptkbp:chemicalFormula
|
C12H11ClN2O5S
|
|
gptkbp:contraindication
|
sulfa allergy
anuria
|
|
gptkbp:discoveredBy
|
gptkb:Hoechst_AG
|
|
gptkbp:discoveredIn
|
1962
|
|
gptkbp:eliminationHalfLife
|
1.5 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:genericAvailable
|
true
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
frusemide
|
|
gptkbp:interactsWith
|
gptkb:NSAIDs
gptkb:digoxin
gptkb:aminoglycosides
lithium
|
|
gptkbp:isApprovedDrug
|
true
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits Na-K-2Cl symporter in thick ascending limb of loop of Henle
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
330.74 g/mol
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:PubChem_CID
|
3440
DB00695
|
|
gptkbp:riskFactor
|
gout
renal impairment
electrolyte imbalance
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
dehydration
hypokalemia
hypotension
ototoxicity
hyperuricemia
|
|
gptkbp:UNII
|
7LXU5N7ZO5
|
|
gptkbp:usedFor
|
congestive heart failure
edema
hypertension
chronic kidney disease
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:bfsParent
|
gptkb:Flusapex
|
|
gptkbp:bfsLayer
|
8
|