fludrocortisone

URI: https://gptkb.org/entity/fludrocortisone

GPTKB entity

Statements (56)

Predicate	Object
gptkbp:instanceOf	gptkb:synthetic_corticosteroid gptkb:drug gptkb:mineralocorticoid
gptkbp:approvedBy	gptkb:United_States
gptkbp:ATCCode	H02AA02
gptkbp:brand	Florinef
gptkbp:CASNumber	127-31-1
gptkbp:category	cardiology endocrinology
gptkbp:chemicalClass	gptkb:Corticosteroid fluorinated steroid
gptkbp:contraindication	systemic fungal infection hypersensitivity to fludrocortisone
gptkbp:discoveredBy	gptkb:Upjohn
gptkbp:eliminationHalfLife	18-36 hours
gptkbp:excretion	renal
gptkbp:form	gptkb:tablet
gptkbp:hasMolecularFormula	C21H29FO5
gptkbp:introducedIn	1954
gptkbp:IUPACName	(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	glucocorticoid receptor agonist (weak) mineralocorticoid receptor agonist
gptkbp:meltingPoint	265°C
gptkbp:metabolism	hepatic
gptkbp:origin	synthetic derivative of cortisol
gptkbp:pregnancyCategory	C (US)
gptkbp:prescribes	postural hypotension adults with Addison's disease pediatric patients with congenital adrenal hyperplasia
gptkbp:proteinBinding	70%
gptkbp:PubChem_CID	5865 5660 CHEMBL1200697 DB00687
gptkbp:routeOfAdministration	oral
gptkbp:sideEffect	heart failure edema headache hypertension hypokalemia
gptkbp:solubility	practically insoluble in water
gptkbp:synonym	9α-fluorocortisol 9α-fluoro-11β,17α,21-trihydroxypregn-4-ene-3,20-dione
gptkbp:UNII	8VZV102JFY
gptkbp:usedFor	gptkb:orthostatic_hypotension Addison's disease adrenal insufficiency salt-losing adrenogenital syndrome
gptkbp:WHOModelListOfEssentialMedicines	yes
gptkbp:bfsParent	gptkb:postural_orthostatic_tachycardia_syndrome gptkb:pure_autonomic_failure gptkb:orthostatic_hypotension gptkb:Primary_Adrenal_Insufficiency
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	fludrocortisone