|
gptkbp:instanceOf
|
gptkb:brain_tumor
gptkb:glioma
|
|
gptkbp:canBeMalignant
|
true
|
|
gptkbp:canProgressTo
|
gptkb:glioblastoma
gptkb:anaplastic_astrocytoma
|
|
gptkbp:definedIn
|
WHO Classification of Tumors of the Central Nervous System
|
|
gptkbp:hasEpidemiology
|
slight male predominance
more common in young adults
|
|
gptkbp:hasICDOCode
|
9400/3
|
|
gptkbp:hasImagingFeature
|
T2 hyperintensity on MRI
minimal contrast enhancement
poorly defined margins
|
|
gptkbp:hasMedianSurvival
|
5-8 years
|
|
gptkbp:hasMolecularSubtype
|
gptkb:IDH-wildtype
IDH-mutant
|
|
gptkbp:hasProliferationIndex
|
low
|
|
gptkbp:hasRecurrencePattern
|
local recurrence
|
|
gptkbp:hasRecurrenceRisk
|
high
|
|
gptkbp:hasWHOGrade
|
II
|
|
gptkbp:histology
|
increased cellularity
no microvascular proliferation
no mitotic activity
no necrosis
nuclear atypia
|
|
gptkbp:ICD-10_code
|
C71
|
|
gptkbp:isInfiltrative
|
true
|
|
gptkbp:location
|
frontal lobe
temporal lobe
cerebral hemispheres
|
|
gptkbp:mutationAssociatedWith
|
gptkb:TP53_mutation
IDH1 mutation
ATRX mutation
IDH2 mutation
|
|
gptkbp:originatedIn
|
astrocyte
|
|
gptkbp:prognosis
|
variable
|
|
gptkbp:riskFactor
|
gptkb:neurofibromatosis_type_1
genetic predisposition
|
|
gptkbp:symptom
|
headache
seizures
neurological deficit
|
|
gptkbp:synonym
|
WHO grade II astrocytoma
low-grade astrocytoma
|
|
gptkbp:treatment
|
gptkb:radiation_therapy
chemotherapy
surgical resection
|
|
gptkbp:bfsParent
|
gptkb:anaplastic_astrocytoma
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
diffuse astrocytoma
|