Statements (48)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
brain tumor
glioma |
| gptkbp:canBeMalignant |
true
|
| gptkbp:canProgressTo |
gptkb:glioblastoma
gptkb:anaplastic_astrocytoma |
| gptkbp:definedIn |
WHO Classification of Tumors of the Central Nervous System
|
| gptkbp:hasEpidemiology |
slight male predominance
more common in young adults |
| gptkbp:hasICDOCode |
9400/3
|
| gptkbp:hasImagingFeature |
T2 hyperintensity on MRI
minimal contrast enhancement poorly defined margins |
| gptkbp:hasMedianSurvival |
5-8 years
|
| gptkbp:hasMolecularSubtype |
gptkb:IDH-wildtype
IDH-mutant |
| gptkbp:hasProliferationIndex |
low
|
| gptkbp:hasRecurrencePattern |
local recurrence
|
| gptkbp:hasRecurrenceRisk |
high
|
| gptkbp:hasWHOGrade |
II
|
| gptkbp:histology |
increased cellularity
no microvascular proliferation no mitotic activity no necrosis nuclear atypia |
| https://www.w3.org/2000/01/rdf-schema#label |
diffuse astrocytoma
|
| gptkbp:ICD-10_code |
C71
|
| gptkbp:isInfiltrative |
true
|
| gptkbp:location |
frontal lobe
temporal lobe cerebral hemispheres |
| gptkbp:mutationAssociatedWith |
gptkb:TP53_mutation
IDH1 mutation ATRX mutation IDH2 mutation |
| gptkbp:originatedIn |
astrocyte
|
| gptkbp:prognosis |
variable
|
| gptkbp:riskFactor |
gptkb:neurofibromatosis_type_1
genetic predisposition |
| gptkbp:symptom |
headache
seizures neurological deficit |
| gptkbp:synonym |
WHO grade II astrocytoma
low-grade astrocytoma |
| gptkbp:treatment |
radiation therapy
chemotherapy surgical resection |
| gptkbp:bfsParent |
gptkb:glioma
|
| gptkbp:bfsLayer |
6
|