complement component C2

GPTKB entity

Statements (27)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName C2
C2a fragment
C2b fragment
complement C2
gptkbp:cleavage gptkb:C1s
gptkbp:deficiencyAssociatedWith autoimmune diseases
gptkbp:deficiencyCauses increased susceptibility to bacterial infections
gptkbp:encodedBy C2 gene
gptkbp:expressedIn liver
gptkbp:form C3 convertase (C4b2a)
gptkbp:formsComplexWith complement component C4b
gptkbp:foundIn gptkb:human
other mammals
gptkbp:function immune response
cleavage to form C2a and C2b fragments
gptkbp:HGNC_ID HGNC:1323
https://www.w3.org/2000/01/rdf-schema#label complement component C2
gptkbp:locatedOnChromosome gptkb:6p21.3
gptkbp:molecularWeight 102 kDa (precursor)
gptkbp:OMIM 217000
gptkbp:partOf gptkb:lectin_pathway
classical complement pathway
gptkbp:presentIn blood plasma
gptkbp:UniProtID P06681
gptkbp:bfsParent gptkb:Mannose-binding_lectin
gptkbp:bfsLayer 7