choline acetyltransferase

URI: https://gptkb.org/entity/choline_acetyltransferase
GPTKB entity
Statements (29)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeSplicing produces multiple isoforms
gptkbp:associatedWith gptkb:Alzheimer's_disease
gptkbp:catalyzes synthesis of acetylcholine
gptkbp:deficiencyCauses gptkb:congenital_myasthenic_syndrome
gptkbp:discoveredBy gptkb:Eugene_Roberts
gptkbp:EC_number 2.3.1.6
gptkbp:expressedIn central nervous system
peripheral nervous system
gptkbp:foundIn presynaptic nerve terminals
gptkbp:gene CHAT
gptkbp:GO_function choline O-acetyltransferase activity
https://www.w3.org/2000/01/rdf-schema#label choline acetyltransferase
gptkbp:importantFor cholinergic neurotransmission
gptkbp:inhibitedBy gptkb:bromoacetylcholine
acetylcoenzyme A analogs
gptkbp:locale gptkb:cytoplasm
gptkbp:molecularWeight ~70 kDa
gptkbp:product gptkb:Coenzyme_A
gptkb:acetylcholine
gptkbp:requires acetylcholine biosynthesis
gptkbp:structure monomeric protein
gptkbp:substrate gptkb:choline
acetyl-CoA
gptkbp:UniProtID P28329
gptkbp:used_as_marker_for cholinergic neurons
gptkbp:bfsParent gptkb:PC12
gptkb:acetylcholine
gptkbp:bfsLayer 7