choline acetyltransferase

URI: https://gptkb.org/entity/choline_acetyltransferase

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:alternativeSplicing	produces multiple isoforms
gptkbp:associatedWith	gptkb:Alzheimer's_disease
gptkbp:catalyzes	synthesis of acetylcholine
gptkbp:deficiencyCauses	gptkb:congenital_myasthenic_syndrome
gptkbp:discoveredBy	gptkb:Eugene_Roberts
gptkbp:EC_number	2.3.1.6
gptkbp:expressedIn	central nervous system peripheral nervous system
gptkbp:foundIn	presynaptic nerve terminals
gptkbp:gene	CHAT
gptkbp:GO_function	choline O-acetyltransferase activity
gptkbp:importantFor	cholinergic neurotransmission
gptkbp:inhibitedBy	gptkb:bromoacetylcholine acetylcoenzyme A analogs
gptkbp:locale	gptkb:cytoplasm
gptkbp:molecularWeight	~70 kDa
gptkbp:product	gptkb:Coenzyme_A gptkb:acetylcholine
gptkbp:requires	acetylcholine biosynthesis
gptkbp:structure	monomeric protein
gptkbp:substrate	gptkb:choline acetyl-CoA
gptkbp:UniProtID	P28329
gptkbp:used_as_marker_for	cholinergic neurons
gptkbp:bfsParent	gptkb:acetylcholine
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	choline acetyltransferase