caspase-activated DNase (CAD)
GPTKB entity
Statements (22)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activatedBy |
gptkb:caspase-3
|
| gptkbp:alsoKnownAs |
DNA fragmentation factor subunit beta (DFFB)
|
| gptkbp:cleavage |
chromosomal DNA
|
| gptkbp:discoveredIn |
1998
|
| gptkbp:EC_number |
3.1.21.-
|
| gptkbp:formsComplexWith |
gptkb:ICAD
|
| gptkbp:function |
endonuclease
DNA fragmentation during apoptosis |
| gptkbp:gene |
DFFB gene
|
| https://www.w3.org/2000/01/rdf-schema#label |
caspase-activated DNase (CAD)
|
| gptkbp:inhibitedBy |
ICAD (inhibitor of CAD)
|
| gptkbp:location |
gptkb:nucleus
|
| gptkbp:molecularWeight |
~40 kDa
|
| gptkbp:releaseYear |
caspase-mediated cleavage of ICAD
|
| gptkbp:role |
apoptosis
|
| gptkbp:species |
gptkb:human
gptkb:mouse |
| gptkbp:structure |
contains N-terminal and C-terminal domains
|
| gptkbp:UniProtID |
O00273
|
| gptkbp:bfsParent |
gptkb:DFF1
|
| gptkbp:bfsLayer |
7
|