Statements (25)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:chemical_compound
|
| gptkbp:category |
oral hypoglycemic agents
|
| gptkbp:compatibleWith |
type 1 diabetes
|
| gptkbp:contains |
gptkb:metformin
gptkb:phenformin buformin |
| gptkbp:contraindication |
renal impairment
|
| gptkbp:discoveredIn |
1920s
|
| gptkbp:hasApprovedDrug |
gptkb:metformin
|
| https://www.w3.org/2000/01/rdf-schema#label |
biguanides
|
| gptkbp:mechanismOfAction |
increases insulin sensitivity
inhibits hepatic gluconeogenesis |
| gptkbp:metforminBrandName |
gptkb:Glucophage
|
| gptkbp:origin |
synthesized from galegine (from Galega officinalis)
|
| gptkbp:routeOfAdministration |
oral
|
| gptkbp:sideEffect |
lactic acidosis
|
| gptkbp:structureContains |
two guanidine groups
|
| gptkbp:usedAs |
antidiabetic agent
|
| gptkbp:usedFor |
gptkb:type_2_diabetes
|
| gptkbp:withdrawnDrug |
gptkb:phenformin
buformin |
| gptkbp:bfsParent |
gptkb:DB00230
gptkb:DB00363 gptkb:dimethylguanylguanidine |
| gptkbp:bfsLayer |
7
|