Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alsoKnownAs |
ENPP2
|
| gptkbp:associatedWith |
gptkb:cancer
fibrosis chronic inflammation |
| gptkbp:catalyzes |
hydrolysis of lysophosphatidylcholine to lysophosphatidic acid
|
| gptkbp:discoveredBy |
Umezu-Goto et al.
|
| gptkbp:discoveredIn |
2002
|
| gptkbp:EC_number |
3.1.4.39
|
| gptkbp:encodedBy |
ENPP2 gene
|
| gptkbp:expressedIn |
gptkb:human
gptkb:mouse right |
| gptkbp:foundIn |
extracellular space
|
| gptkbp:function |
lysophospholipase D activity
|
| https://www.w3.org/2000/01/rdf-schema#label |
autotaxin
|
| gptkbp:involvedIn |
lipid metabolism
cell motility tumor progression |
| gptkbp:locatedOnChromosome |
gptkb:8q24.12
|
| gptkbp:molecularWeight |
~100 kDa
|
| gptkbp:potentialTherapeuticTargetFor |
gptkb:cancer
fibrotic diseases |
| gptkbp:structure |
contains nuclease-like domain
contains phosphodiesterase domain contains somatomedin B-like domains |
| gptkbp:target |
pharmacological inhibitors
|
| gptkbp:UniProtID |
Q13822
|
| gptkbp:bfsParent |
gptkb:Lysophosphatidic_acid
|
| gptkbp:bfsLayer |
6
|