artemisinin combination therapy

GPTKB entity

Predicate	Object
gptkbp:instanceOf	antimalarial treatment
gptkbp:contraindication	first trimester pregnancy (some combinations)
gptkbp:developedBy	1990s
gptkbp:example	gptkb:artesunate-amodiaquine gptkb:artesunate-mefloquine gptkb:artesunate-sulfadoxine-pyrimethamine gptkb:dihydroartemisinin-piperaquine gptkb:artemether-lumefantrine
gptkbp:hasComponent	artemisinin derivative partner drug
https://www.w3.org/2000/01/rdf-schema#label	artemisinin combination therapy
gptkbp:mechanismOfAction	rapid parasite clearance
gptkbp:notRecommendedFor	severe malaria (monotherapy preferred)
gptkbp:origin	gptkb:China
gptkbp:partnerDrugPurpose	prevent resistance prolong antimalarial effect
gptkbp:recommendation	gptkb:World_Health_Organization
gptkbp:reduces	malaria parasite resistance
gptkbp:routeOfAdministration	oral intravenous
gptkbp:sideEffect	nausea vomiting dizziness headache
gptkbp:usedFor	malaria
gptkbp:WHORecommendedFirstLine	uncomplicated Plasmodium falciparum malaria
gptkbp:bfsParent	gptkb:Plasmodium_malariae
gptkbp:bfsLayer	5