|
gptkbp:instance_of
|
gptkb:pharmaceuticals
|
|
gptkbp:administered_by
|
oral tablet
|
|
gptkbp:approves
|
gptkb:2001
gptkb:World_Health_Organization
|
|
gptkbp:availability
|
prescription only
|
|
gptkbp:can_be_combined_with
|
antimalarial agents
artemisinin derivatives
|
|
gptkbp:clinical_trial
|
studied in various countries
|
|
gptkbp:clinical_use
|
second-line treatment
first-line treatment
|
|
gptkbp:contains
|
gptkb:dihydroartemisinin
gptkb:piperaquine
|
|
gptkbp:contraindication
|
hypersensitivity to piperaquine
hypersensitivity to artemisinin
|
|
gptkbp:developed_by
|
Artemisinin-based combination therapy
|
|
gptkbp:dosage_form
|
tablets
suspensions
|
|
gptkbp:formulation
|
fixed-dose combination
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
dihydroartemisinin-piperaquine
|
|
gptkbp:interacts_with
|
may interact with other antimalarials
|
|
gptkbp:invention
|
patented
|
|
gptkbp:is_effective_against
|
high cure rates
|
|
gptkbp:is_recommended_by
|
gptkb:CDC
gptkb:WHO
|
|
gptkbp:is_recommended_for
|
uncomplicated malaria
|
|
gptkbp:marketed_as
|
Duo-Cotecxin
|
|
gptkbp:mechanism_of_action
|
antimalarial activity
|
|
gptkbp:pharmacokinetics
|
long half-life
rapid absorption
|
|
gptkbp:research
|
ongoing studies
long-term effects
safety in children
safety in pregnancy
efficacy against resistant strains
|
|
gptkbp:safety
|
generally well tolerated
|
|
gptkbp:side_effect
|
dizziness
headache
nausea
vomiting
|
|
gptkbp:storage
|
store at room temperature
protect from moisture
|
|
gptkbp:used_for
|
treatment of malaria
|
|
gptkbp:used_in
|
gptkb:Southeast_Asia
gptkb:sub-Saharan_Africa
tropical regions
|
|
gptkbp:bfsParent
|
gptkb:dihydroartemisinin
gptkb:artemisinin-based_combination_therapies_(ACTs)
|
|
gptkbp:bfsLayer
|
8
|