artemisinin

URI: https://gptkb.org/entity/artemisinin
GPTKB entity
Statements (52)
Predicate Object
gptkbp:instanceOf antiviral drug
sesquiterpene lactone
gptkbp:administeredBy oral route
intravenous route
gptkbp:approvedBy gptkb:Africa
gptkb:China
gptkb:Vietnam
gptkbp:ATCCode gptkb:P01BE01
gptkbp:awarded gptkb:Nobel_Prize_in_Physiology_or_Medicine_(2015,_Tu_Youyou)
gptkbp:boilingPoint decomposes
gptkbp:CASNumber 63968-64-9
gptkbp:category gptkb:WHO_essential_medicine
natural product
antimalarial
antineoplastic agent
endoperoxide
lactone
phytochemical
sesquiterpene
gptkbp:chemicalFormula C15H22O5
gptkbp:contraindication hypersensitivity
gptkbp:discoveredBy gptkb:Tu_Youyou
gptkbp:eliminationHalfLife 1-2 hours
gptkbp:firstIsolatedFrom 1972
gptkbp:foundIn gptkb:sweet_wormwood
https://www.w3.org/2000/01/rdf-schema#label artemisinin
gptkbp:includedIn gptkb:WHO_Model_List_of_Essential_Medicines
gptkbp:IUPACName (3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-Trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
gptkbp:mechanismOfAction produces free radicals that damage malaria parasites
gptkbp:meltingPoint 156-157 °C
gptkbp:metabolism liver
gptkbp:molecularWeight 282.33 g/mol
gptkbp:notableDerivative gptkb:artemether
gptkb:artesunate
gptkb:dihydroartemisinin
gptkb:artemotil
gptkbp:notRecommendedFor monotherapy
gptkbp:originatedIn gptkb:Artemisia_annua
gptkbp:PubChem_CID 68827
gptkbp:recommendation combination drug
gptkbp:sideEffect nausea
vomiting
anorexia
dizziness
gptkbp:solubility poorly soluble in water
soluble in organic solvents
gptkbp:UNII KQ1C2X84UI
gptkbp:usedFor treatment of malaria
gptkbp:bfsParent gptkb:Project_523
gptkb:Tu_Youyou
gptkb:Plasmodium_falciparum
gptkbp:bfsLayer 5