|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:affiliatedWith
|
class I aminoacyl-tRNA synthetase family
|
|
gptkbp:alternativeName
|
ArgRS
arginine--tRNA ligase
arginine-tRNA synthetase
|
|
gptkbp:associatedWith
|
multi-synthetase complex (in higher eukaryotes)
|
|
gptkbp:biologicalProcess
|
translator
|
|
gptkbp:catalyzes
|
attachment of arginine to tRNA(Arg)
|
|
gptkbp:cofactor
|
Mg2+
|
|
gptkbp:conservedIn
|
all domains of life
|
|
gptkbp:EC_number
|
6.1.1.19
|
|
gptkbp:encodedBy
|
RARS gene (human)
|
|
gptkbp:expressedIn
|
all tissues
|
|
gptkbp:firstDescribed
|
1960s
|
|
gptkbp:foundIn
|
gptkb:Bacteria
archaea
eukaryotes
|
|
gptkbp:function
|
aminoacylation of tRNA with arginine
|
|
gptkbp:gene
|
RARS
|
|
gptkbp:has_active_site
|
gptkb:Rossmann_fold
|
|
gptkbp:has_disease_variant
|
CMT2D-associated mutations
|
|
gptkbp:hasIsoform
|
cytoplasmic
mitochondrial (in some species)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
arginyl-tRNA synthetase
|
|
gptkbp:inhibitedBy
|
arginine analogs
|
|
gptkbp:interactsWith
|
other aminoacyl-tRNA synthetases (in multi-synthetase complex)
|
|
gptkbp:locatedIn
|
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
5q31.3
|
|
gptkbp:molecular_function_(GO)
|
arginine-tRNA ligase activity
|
|
gptkbp:mutationAssociatedWith
|
Charcot-Marie-Tooth disease type 2D
|
|
gptkbp:OMIM_ID_(human)
|
107820
|
|
gptkbp:ortholog_in_E._coli
|
argS
|
|
gptkbp:orthologInYeast
|
RRS1
|
|
gptkbp:participatedIn
|
protein biosynthesis
|
|
gptkbp:PDB
|
yes
|
|
gptkbp:product
|
gptkb:AMP
pyrophosphate
arginyl-tRNA(Arg)
|
|
gptkbp:proteinFamily
|
PF00587
|
|
gptkbp:requires
|
cell viability
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:structure
|
monomer or dimer (species-dependent)
|
|
gptkbp:substrate
|
gptkb:ATP
gptkb:L-arginine
tRNA(Arg)
|
|
gptkbp:UniProtID
|
P54136
|
|
gptkbp:bfsParent
|
gptkb:class_I_aminoacyl-tRNA_synthetase
|
|
gptkbp:bfsLayer
|
7
|