anaplastic thyroid cancer

URI: https://gptkb.org/entity/anaplastic_thyroid_cancer

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:cancer
gptkbp:affectsOrgan	thyroid gland
gptkbp:alternativeName	undifferentiated thyroid carcinoma
gptkbp:firstDescribed	1907
gptkbp:has5YearSurvivalRate	<10%
gptkbp:hasCommonComplication	death airway obstruction distant metastasis local invasion
gptkbp:hasCommonMetastasisSites	brain lungs bones
gptkbp:hasCommonSymptoms	hoarseness dyspnea dysphagia rapidly enlarging neck mass
gptkbp:hasCommonTherapy	palliative care multimodal therapy
gptkbp:hasDiagnosticMethod	gptkb:CT_scan imaging MRI ultrasound biopsy fine needle aspiration
gptkbp:hasGenderPrevalence	slightly more common in females
gptkbp:hasGeneticAlteration	gptkb:TP53_mutation BRAF mutation TERT promoter mutation
gptkbp:hasICD-O-3Code	8021/3
gptkbp:hasMedianSurvival	<6 months
gptkbp:hasMetastasisRateAtDiagnosis	>50%
gptkbp:hasPercentageOfThyroidCancers	<2%
gptkbp:hasTypicalAgeOfOnset	>60 years
gptkbp:hasTypicalPresentation	locally advanced disease
gptkbp:histology	undifferentiated
https://www.w3.org/2000/01/rdf-schema#label	anaplastic thyroid cancer
gptkbp:ICD-10_code	gptkb:C73
gptkbp:mortalityRate	very high
gptkbp:originatedIn	follicular cells
gptkbp:prevalence	rare
gptkbp:prognosis	poor
gptkbp:riskFactor	older age history of goiter previous thyroid disease
gptkbp:stageName	gptkb:AJCC_TNM
gptkbp:treatment	surgery radiation therapy chemotherapy targeted therapy
gptkbp:bfsParent	gptkb:cancer
gptkbp:bfsLayer	4