alpha-amanitin

URI: https://gptkb.org/entity/alpha-amanitin
GPTKB entity
Statements (34)
Predicate Object
gptkbp:instanceOf gptkb:Dragon
gptkbp:antidote no specific antidote
gptkbp:CASNumber 23109-05-9
gptkbp:category gptkb:amatoxin
mycotoxin
hepatotoxin
nephrotoxin
gptkbp:cause kidney failure
liver failure
gptkbp:chemicalFormula C39H54N10O14S
gptkbp:discoveredBy gptkb:Heinz_Wieland
gptkbp:discoveredIn 1941
gptkbp:foundIn gptkb:Amanita_bisporigera
gptkb:Amanita_phalloides
gptkb:Amanita_virosa
https://www.w3.org/2000/01/rdf-schema#label alpha-amanitin
gptkbp:isCyclicPeptide true
gptkbp:IUPACName (3S,6R,9S,12R,15S,18R,21S,24R,27S,30R)-6,9,12,15,18,21,24,27-octakis(2-amino-2-oxoethyl)-3,30-bis(2-hydroxyethyl)-1,4,7,10,13,16,19,22,25,28,31,34-dodecaazatricyclo[33.3.0.0^{9,15}]tetratriaconta-1(35),2,4,7,10,13,16,19,22,25,28,31,34-tridecaene-2,5,8,11,14,17,20,23,26,29,32,35-dodecone
gptkbp:KEGGID C08261
gptkbp:LD50 0.1 mg/kg (mouse, intravenous)
gptkbp:mechanismOfAction inhibits RNA polymerase II
gptkbp:molecularWeight 918.0 g/mol
gptkbp:producedBy gptkb:Amanita_mushrooms
gptkbp:PubChem_CID CHEMBL1234892
139600
gptkbp:relatedTo gptkb:amanitin
gptkb:beta-amanitin
gptkb:gamma-amanitin
gptkbp:routeOfExposure ingestion
gptkbp:toxicity highly toxic
gptkbp:treatment supportive care
gptkbp:UNII 6T3D8K0U6U
gptkbp:bfsParent gptkb:amatoxins
gptkbp:bfsLayer 5