adipose triglyceride lipase (ATGL)

URI: https://gptkb.org/entity/adipose_triglyceride_lipase_(ATGL)
GPTKB entity
Statements (29)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alsoKnownAs patatin-like phospholipase domain-containing protein 2
gptkbp:discoveredBy 2004
gptkbp:EC_number 3.1.1.3
gptkbp:encodedBy gptkb:PNPLA2_gene
gptkbp:function hydrolyzes triglycerides into diacylglycerol and free fatty acids
gptkbp:gene gptkb:PNPLA2
https://www.w3.org/2000/01/rdf-schema#label adipose triglyceride lipase (ATGL)
gptkbp:locatedOnChromosome gptkb:chromosome_11p15.5
gptkbp:location adipose tissue
cytosol
lipid droplets
gptkbp:molecularWeight 54 kDa
gptkbp:mutationAssociatedWith gptkb:neutral_lipid_storage_disease_with_myopathy
neutral lipid storage disease with ichthyosis
gptkbp:OMIM 609059
gptkbp:product diacylglycerol
free fatty acids
gptkbp:regulates inhibited by G0/G1 switch gene 2 (G0S2)
activated by comparative gene identification-58 (CGI-58)
gptkbp:role lipolysis
energy homeostasis
gptkbp:species gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:structure contains patatin domain
gptkbp:substrate triglyceride
gptkbp:UniProtID gptkb:Q96AD5
gptkbp:bfsParent gptkb:G0S2
gptkbp:bfsLayer 8