acute graft-versus-host disease
GPTKB entity
Statements (43)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:disease
immune system disorder |
| gptkbp:affects |
gptkb:skin
gastrointestinal tract liver recipients of allogeneic hematopoietic stem cell transplantation |
| gptkbp:alsoKnownAs |
acute GVHD
|
| gptkbp:cause |
gptkb:chronic_graft-versus-host_disease
|
| gptkbp:causedBy |
donor immune cells attacking host tissues
|
| gptkbp:complication |
gptkb:allogeneic_stem_cell_transplantation
allogeneic bone marrow transplantation |
| gptkbp:diagnosedBy |
laboratory tests
biopsy clinical presentation |
| gptkbp:field |
immunology
hematology |
| gptkbp:firstDescribed |
1966
|
| https://www.w3.org/2000/01/rdf-schema#label |
acute graft-versus-host disease
|
| gptkbp:ICD-10_code |
T86.0
|
| gptkbp:MeSH_ID |
gptkb:D005778
|
| gptkbp:mortalityRate |
high in severe cases
|
| gptkbp:prevention |
immunosuppressive prophylaxis
T-cell depletion of graft |
| gptkbp:riskFactor |
gptkb:HLA_mismatch
female donor to male recipient older age of donor or recipient |
| gptkbp:stageName |
grade I
grade II grade III grade IV |
| gptkbp:symptom |
nausea
vomiting diarrhea abdominal pain jaundice skin rash liver dysfunction |
| gptkbp:treatment |
gptkb:antithymocyte_globulin
immunosuppressive therapy corticosteroids calcineurin inhibitors |
| gptkbp:bfsParent |
gptkb:graft-versus-host_disease
|
| gptkbp:bfsLayer |
6
|