Zopiclone

GPTKB entity

Statements (53)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
sedative
gptkbp:antidote flumazenil (limited efficacy)
gptkbp:ATCCode N05CF01
gptkbp:bioavailability ~80% (oral)
gptkbp:brand gptkb:Imovane
gptkb:Zimovane
gptkb:Zopitan
gptkbp:CASNumber 43200-80-2
gptkbp:chemicalFormula contains a pyrrolopyrazine ring
gptkbp:controlledSubstanceSchedule gptkb:Australia
gptkb:United_Kingdom
gptkb:United_States
gptkbp:developedBy gptkb:Rhône-Poulenc
gptkbp:drugClass cyclopyrrolone
gptkbp:eliminationHalfLife about 5 hours
gptkbp:excretion gptkb:kidney
gptkbp:hasMolecularFormula C17H17ClN6O3
https://www.w3.org/2000/01/rdf-schema#label Zopiclone
gptkbp:interactsWith gptkb:beer
gptkb:CNS_depressants
CYP3A4 inhibitors
gptkbp:IUPACName gptkb:6-(5-chloro-2-pyridyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl_4-methylpiperazine-1-carboxylate
gptkbp:legalStatus prescription only
gptkbp:marketedAs 1986
gptkbp:mechanismOfAction modulates GABA-A receptor
gptkbp:meltingPoint 178–180 °C
gptkbp:metabolism liver
gptkbp:notRecommendedFor children
pregnancy
breastfeeding
gptkbp:overdoseSymptoms coma
respiratory depression
gptkbp:pregnancyCategory gptkb:C_(Australia)
C (US)
gptkbp:proteinBinding ~45%
gptkbp:PubChem_CID gptkb:CHEMBL1092
5738
5534
gptkbp:riskFactor tolerance
dependence
withdrawal symptoms
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:center
dizziness
headache
drowsiness
dry mouth
bitter taste
gptkbp:UNII UHS5N8K95T
gptkbp:usedFor treatment of insomnia
gptkbp:bfsParent gptkb:Nonbenzodiazepine_hypnotics
gptkbp:bfsLayer 6