|
gptkbp:instanceOf
|
gptkb:drug
anticonvulsant
|
|
gptkbp:approvalYear
|
1989
2000
|
|
gptkbp:approvedBy
|
gptkb:Japan
gptkb:United_States
|
|
gptkbp:ATCCode
|
N03AX15
|
|
gptkbp:brand
|
Zonegran
|
|
gptkbp:CASNumber
|
68291-97-4
|
|
gptkbp:chemicalClass
|
sulfonamide
|
|
gptkbp:contraindication
|
sulfonamide allergy
|
|
gptkbp:discoveredBy
|
gptkb:Dainippon_Sumitomo_Pharma
|
|
gptkbp:eliminationHalfLife
|
63 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:genericName
|
yes
|
|
gptkbp:hasMolecularFormula
|
C8H8N2O3S
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Zonisamide
|
|
gptkbp:interactsWith
|
gptkb:phenytoin
gptkb:valproic_acid
gptkb:carbamazepine
phenobarbital
oral contraceptives
|
|
gptkbp:KEGGID
|
D08667
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
blocks sodium channels
inhibits T-type calcium channels
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:proteinBinding
|
40%
|
|
gptkbp:PubChem_CID
|
5736
CHEMBL1201
DB00909
|
|
gptkbp:riskFactor
|
suicidal thoughts
hyperthermia
metabolic acidosis
oligohidrosis
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gptkb:depression
dizziness
loss of appetite
weight loss
rash
drowsiness
kidney stones
|
|
gptkbp:synonym
|
1,2-benzisoxazole-3-methanesulfonamide
|
|
gptkbp:UNII
|
7NNO0D7S5M
|
|
gptkbp:usedFor
|
gptkb:Lennox-Gastaut_syndrome
epilepsy
infantile spasms
partial seizures
|
|
gptkbp:bfsParent
|
gptkb:Epileptic_Dogs
|
|
gptkbp:bfsLayer
|
6
|