Vitamin D receptor

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
nuclear receptor
gptkbp:alternativeName gptkb:NR1I1
calcitriol receptor
gptkbp:associatedWith gptkb:bone
autoimmune diseases
hereditary vitamin D-resistant rickets
gptkbp:binds gptkb:1,25-dihydroxyvitamin_D3
gptkbp:encodedBy VDR gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000111424
7421
gptkbp:expressedIn gptkb:bone
gptkb:kidney
parathyroid gland
intestine
immune cells
gptkbp:firstDescribed 1969
gptkbp:formsHeterodimerWith retinoid X receptor
gptkbp:foundIn humans
mammals
gptkbp:function regulates gene expression
mediates effects of vitamin D
gptkbp:gene gptkb:VDR
gptkbp:gene_length_(human) ~100 kb
gptkbp:HGNC_ID 12679
https://www.w3.org/2000/01/rdf-schema#label Vitamin D receptor
gptkbp:locatedOnChromosome 12q13.11
gptkbp:member nuclear receptor subfamily 1 group I member 1
gptkbp:MIM_gene 601769
gptkbp:modulatedBy cell differentiation
cell proliferation
inflammation
immune response
gptkbp:OMIM 601769
gptkbp:orthologIn gptkb:mouse
gptkb:zebrafish
right
gptkbp:PDB 1IE9
gptkbp:protein_length_(human) 427 amino acids
gptkbp:regulates calcium homeostasis
phosphate homeostasis
bone mineralization
gptkbp:structure contains DNA-binding domain
contains ligand-binding domain
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
gptkbp:target vitamin D analogs
gptkbp:UniProtID P11473
gptkbp:bfsParent gptkb:VDR
gptkbp:bfsLayer 7