|
gptkbp:instanceOf
|
gptkb:nuclear_receptor
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:NR1I1
calcitriol receptor
|
|
gptkbp:associatedWith
|
gptkb:bone
autoimmune diseases
hereditary vitamin D-resistant rickets
|
|
gptkbp:binds
|
gptkb:1,25-dihydroxyvitamin_D3
|
|
gptkbp:encodedBy
|
VDR gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000111424
7421
|
|
gptkbp:expressedIn
|
gptkb:bone
gptkb:kidney
parathyroid gland
intestine
immune cells
|
|
gptkbp:firstDescribed
|
1969
|
|
gptkbp:formsHeterodimerWith
|
retinoid X receptor
|
|
gptkbp:foundIn
|
humans
mammals
|
|
gptkbp:function
|
regulates gene expression
mediates effects of vitamin D
|
|
gptkbp:gene
|
gptkb:VDR
|
|
gptkbp:gene_length_(human)
|
~100 kb
|
|
gptkbp:HGNC_ID
|
12679
|
|
gptkbp:locatedOnChromosome
|
12q13.11
|
|
gptkbp:member
|
nuclear receptor subfamily 1 group I member 1
|
|
gptkbp:MIM_gene
|
601769
|
|
gptkbp:modulatedBy
|
gptkb:immune_response
cell differentiation
cell proliferation
inflammation
|
|
gptkbp:OMIM
|
601769
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:right
gptkb:zebrafish
|
|
gptkbp:PDB
|
1IE9
|
|
gptkbp:protein_length_(human)
|
427 amino acids
|
|
gptkbp:regulates
|
calcium homeostasis
phosphate homeostasis
bone mineralization
|
|
gptkbp:structure
|
contains DNA-binding domain
contains ligand-binding domain
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:target
|
vitamin D analogs
|
|
gptkbp:UniProtID
|
P11473
|
|
gptkbp:bfsParent
|
gptkb:VDR
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Vitamin D receptor
|