Statements (43)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:abbreviation |
V-ATPase
|
| gptkbp:compatibleWith |
gptkb:Bacteria
archaea |
| gptkbp:component |
gptkb:Golgi_apparatus_membrane
lysosome membrane endosome membrane plasma membrane (in some cells) |
| gptkbp:discoveredIn |
1980s
|
| gptkbp:dysregulationAssociatedWith |
gptkb:osteopetrosis
renal tubular acidosis cancer cell metastasis |
| gptkbp:EC_number |
3.6.3.14
|
| gptkbp:foundIn |
eukaryotic cells
|
| gptkbp:function |
proton pump
acidification of intracellular organelles |
| gptkbp:GO_term |
GO:0015991 (ATP hydrolysis coupled proton transport)
|
| https://www.w3.org/2000/01/rdf-schema#label |
Vacuolar-type H+-ATPase
|
| gptkbp:inhibitedBy |
bafilomycin A1
concanamycin A |
| gptkbp:powerSource |
ATP hydrolysis
|
| gptkbp:presentIn |
gptkb:protists
animals fungi plants |
| gptkbp:proteinFamily |
ATP6V
|
| gptkbp:relatedTo |
F-type ATPase
P-type ATPase |
| gptkbp:role |
protein degradation
receptor-mediated endocytosis bone resorption pH homeostasis neurotransmitter loading renal acidification |
| gptkbp:subunit |
multisubunit complex
V0 domain V1 domain |
| gptkbp:UniProtID |
gptkb:cell_membrane
Ion transport Hydrolase Proton transport |
| gptkbp:bfsParent |
gptkb:Lysosome
|
| gptkbp:bfsLayer |
6
|