Tumor-Associated Macrophages
GPTKB entity
Statements (59)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
Macrophages
|
| gptkbp:associatedWith |
Tumor microenvironment
Poor prognosis |
| gptkbp:built |
Monocytes
|
| gptkbp:canAllocate |
Tumor microenvironment
Tumor-associated gene expression |
| gptkbp:canBe |
Immune tolerance
Fibrosis |
| gptkbp:canEstablish |
gptkb:PD-L1
Tumor cell survival |
| gptkbp:canLeadTo |
Immune cells
|
| gptkbp:canSupport |
Antitumor immunity
|
| gptkbp:community |
Surface markers
|
| gptkbp:contributedTo |
Metastasis
|
| gptkbp:diedIn |
Tissue remodeling
Tumor progression |
| gptkbp:exhibits |
Plasticity
|
| gptkbp:hasInfluenceOn |
gptkb:Cancer_stem_cells
Tumor heterogeneity Tumor metabolism Tumor-associated apoptosis. Tumor-associated signaling pathways |
| https://www.w3.org/2000/01/rdf-schema#label |
Tumor-Associated Macrophages
|
| gptkbp:influence |
Immune response
Chemotherapy response |
| gptkbp:interactsWith |
Cancer cells
|
| gptkbp:introduced |
Cytokines
Growth factors |
| gptkbp:involvedIn |
Inflammation
Tumor immune evasion |
| gptkbp:isChallengedBy |
Checkpoint inhibitors
|
| gptkbp:isCharacterizedBy |
High IL-10 production
Low IL-12 production |
| gptkbp:isCounteredBy |
Cytokines
Immunotherapy |
| gptkbp:isFoundIn |
Solid tumors
Hematological malignancies |
| gptkbp:isIntegratedWith |
Endothelial cells
|
| gptkbp:isInvolvedIn |
Extracellular matrix remodeling
Tumor-associated immune suppression Tumor-associated inflammation Tumor-associated lymphangiogenesis Tumor-associated metabolic reprogramming Therapeutic_resistance |
| gptkbp:isUsedFor |
Matrix metalloproteinases
Chemokines Exosomes M1 macrophages M2 macrophages |
| gptkbp:isVisitedBy |
Hypoxia
Tumor-derived factors |
| gptkbp:mayHave |
Metabolic pathways
Immune checkpoint molecules Tumor cell invasion Tumor-associated angiogenesis Tumor-associated cell proliferation Tumor-associated immune responses |
| gptkbp:modifications |
T-cell activity
|
| gptkbp:promotes |
Angiogenesis
|