Statements (65)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
Stem cells
|
| gptkbp:associated_with |
Tumor heterogeneity
Epithelial-mesenchymal transition Increased metastasis risk Invasive cancer Tumor aggressiveness |
| gptkbp:contributedTo |
Metastasis
|
| gptkbp:culturalHeritage |
Laboratory conditions
|
| gptkbp:divisions |
Bone marrow
Tumor biopsies |
| gptkbp:exhibits |
Self-renewal
|
| gptkbp:has_a_focus_on |
Regenerative medicine
Personalized medicine |
| gptkbp:hasRole |
Tumor initiation
|
| https://www.w3.org/2000/01/rdf-schema#label |
Cancer stem cells
|
| gptkbp:influence |
Tumor microenvironment
Immune evasion |
| gptkbp:influenced |
Hypoxia
Cytokines Epigenetic changes Microenvironmental factors Niche factors |
| gptkbp:is_a_key_component_of |
Tumor-initiating cells
|
| gptkbp:is_a_subject_of |
Clinical trials
|
| gptkbp:is_accessible_by |
Magnetic-activated cell sorting
|
| gptkbp:is_aimed_at |
Gene therapy
Immunotherapy Small molecule inhibitors Novel therapies |
| gptkbp:is_available_in |
Solid tumors
Hematological malignancies |
| gptkbp:is_characterized_by |
Metabolic pathways
Altered signaling pathways Cell surface proteins Gene expression profiles High tumorigenicity Resistance to apoptosis |
| gptkbp:is_involved_in |
Cell cycle regulation
Angiogenesis Cell signaling pathways Drug resistance Tumor progression Chemotherapy resistance Tumor evolution Cellular plasticity Cancer recurrence Therapeutic failure Tumor immune escape |
| gptkbp:is_linked_to |
Poor prognosis
|
| gptkbp:is_recognized_for |
Flow cytometry
Specific markers |
| gptkbp:is_studied_in |
Cancer research
Stem cell biology Tumor microenvironment interactions Biomarker_discovery Therapeutic_targets Therapeutic_resistance_mechanisms |
| gptkbp:isNotableFor |
Conventional therapies
|
| gptkbp:isUsedFor |
Induced pluripotent stem cells
Cancerous tissues |
| gptkbp:originatesFrom |
Normal stem cells
|
| gptkbp:provides |
Specific surface markers
|
| gptkbp:recognizes |
Biomarkers
|
| gptkbp:variant |
Various cell types
|
| gptkbp:worksWith |
Targeted therapies
|