Statements (26)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:TPH
tryptophan 5-monooxygenase |
| gptkbp:catalyzes |
hydroxylation of tryptophan to 5-hydroxytryptophan
|
| gptkbp:cofactor |
gptkb:tetrahydrobiopterin
iron |
| gptkbp:discoveredBy |
1960s
|
| gptkbp:EC_number |
1.14.16.4
|
| gptkbp:expressedIn |
neurons
enterochromaffin cells |
| gptkbp:family |
aromatic amino acid hydroxylase
|
| gptkbp:foundIn |
brain
gut |
| gptkbp:gene |
TPH1
TPH2 |
| https://www.w3.org/2000/01/rdf-schema#label |
Tryptophan hydroxylase
|
| gptkbp:inhibitedBy |
p-chlorophenylalanine
|
| gptkbp:mutationAssociatedWith |
serotonin deficiency
|
| gptkbp:pathway |
serotonin biosynthesis
|
| gptkbp:product |
gptkb:5-hydroxytryptophan
|
| gptkbp:requires |
NADPH
molecular oxygen |
| gptkbp:structure |
homotetramer
|
| gptkbp:substrate |
tryptophan
|
| gptkbp:bfsParent |
gptkb:TPH
|
| gptkbp:bfsLayer |
7
|