Transcription Activator-Like Effector Nuclease gene editing
GPTKB entity
Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gene editing technology
|
| gptkbp:alsoKnownAs |
gptkb:TALEN_gene_editing
|
| gptkbp:basedOn |
Transcription Activator-Like Effectors
|
| gptkbp:contrastsWith |
gptkb:CRISPR-Cas9
Zinc Finger Nucleases |
| gptkbp:developedBy |
2010
|
| gptkbp:enables |
gene knockout
gene correction gene insertion targeted genome editing |
| gptkbp:firstDemonstrated |
gptkb:Joung_Lab
gptkb:Voytas_Lab |
| https://www.w3.org/2000/01/rdf-schema#label |
Transcription Activator-Like Effector Nuclease gene editing
|
| gptkbp:mechanismOfAction |
induces double-strand breaks in DNA
|
| gptkbp:publishedIn |
gptkb:science
gptkb:Nature_Biotechnology |
| gptkbp:requires |
custom protein engineering
|
| gptkbp:usedIn |
animal genome editing
plant genome editing human cell genome editing |
| gptkbp:uses |
gptkb:TALENs
|
| gptkbp:bfsParent |
gptkb:TALEN_gene_editing
|
| gptkbp:bfsLayer |
8
|