Topamax

GPTKB entity

Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 1996
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
gptkbp:ATCCode N03AX11
gptkbp:cause glaucoma
metabolic acidosis
hyperammonemia
kidney stones
oligohidrosis
gptkbp:contraindication pregnancy
allergy to topiramate
gptkbp:drugClass anticonvulsant
antiepileptic
gptkbp:eliminationHalfLife 21 hours
gptkbp:excretion urine
gptkbp:form gptkb:tablet
capsule
gptkbp:genericName gptkb:topiramate
https://www.w3.org/2000/01/rdf-schema#label Topamax
gptkbp:interactsWith gptkb:metformin
gptkb:beer
gptkb:phenytoin
gptkb:warfarin
gptkb:valproic_acid
gptkb:CNS_depressants
gptkb:carbamazepine
gptkb:amitriptyline
gptkb:pioglitazone
gptkb:risperidone
gptkb:hydrochlorothiazide
gptkb:digoxin
lithium
oral contraceptives
gptkbp:legalStatus prescription only
gptkbp:manufacturer gptkb:Janssen_Pharmaceuticals
gptkbp:mechanismOfAction antagonizes AMPA/kainate glutamate receptors
blocks voltage-dependent sodium channels
enhances GABA activity
gptkbp:metabolism liver
gptkbp:pregnancyCategory D (US)
gptkbp:pregnancyWarning may cause birth defects
gptkbp:routeOfAdministration oral
gptkbp:sideEffect dizziness
weight loss
cognitive impairment
drowsiness
paresthesia
gptkbp:usedFor epilepsy
migraine prevention
gptkbp:bfsParent gptkb:topiramate
gptkbp:bfsLayer 7