Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
signaling molecule
biological pathway |
| gptkbp:activatedBy |
gptkb:NF-κB_pathway
antimicrobial peptide genes |
| gptkbp:component |
Cactus protein
Dif protein Dorsal protein MyD88 adaptor protein Pelle kinase Spätzle protein Toll receptor Tube protein |
| gptkbp:discoveredBy |
gptkb:Jules_Hoffmann
|
| gptkbp:discoveredIn |
1996
|
| gptkbp:foundIn |
gptkb:Drosophila_melanogaster
insects vertebrates |
| https://www.w3.org/2000/01/rdf-schema#label |
Toll pathway
|
| gptkbp:involvedIn |
innate immunity
antimicrobial response |
| gptkbp:launched |
recognition of pathogen-associated molecular patterns
|
| gptkbp:namedAfter |
Toll gene
|
| gptkbp:notableWinner |
Nobel Prize in Physiology or Medicine 2011 (to Jules Hoffmann)
|
| gptkbp:recipient |
Toll-like receptor
|
| gptkbp:regulates |
expression of immune genes
|
| gptkbp:relatedTo |
gptkb:Toll-like_receptor_signaling_pathway
|
| gptkbp:role |
defense against fungi
defense against Gram-positive bacteria embryonic development in Drosophila |
| gptkbp:bfsParent |
gptkb:Drosophila_infection_model
|
| gptkbp:bfsLayer |
8
|