Thrombotic thrombocytopenic purpura

URI: https://gptkb.org/entity/Thrombotic_thrombocytopenic_purpura
GPTKB entity
Statements (43)
Predicate Object
gptkbp:instanceOf gptkb:disease
gptkbp:abbreviation gptkb:TTP
gptkbp:age_group_affected adults
children
gptkbp:cause autoimmune disease
ADAMTS13 deficiency
gptkbp:complication stroke
acute kidney injury
gptkbp:diagnostic_test gptkb:lactate_dehydrogenase
blood smear
platelet count
ADAMTS13 activity assay
gptkbp:firstDescribed 1924
gptkbp:frequency rare
gptkbp:hereditary_form Upshaw-Schulman syndrome
https://www.w3.org/2000/01/rdf-schema#label Thrombotic thrombocytopenic purpura
gptkbp:ICD-10_code M31.1
gptkbp:inheritance hereditary
acquired
gptkbp:MeSH_ID D013927
gptkbp:mortality_rate_(treated) 10-20%
gptkbp:mortality_rate_(untreated) >90%
gptkbp:namedAfter Eli Moschcowitz
gptkbp:OMIM 274150
gptkbp:relatedTo gptkb:hemolytic_uremic_syndrome
disseminated intravascular coagulation
gptkbp:riskFactor gptkb:cancer
pregnancy
HIV infection
medications
gptkbp:sex_predominance female
gptkbp:specialty hematology
gptkbp:symptom fever
thrombocytopenia
renal dysfunction
neurological symptoms
microangiopathic hemolytic anemia
gptkbp:treatment gptkb:rituximab
corticosteroids
plasma exchange
caplacizumab
gptkbp:bfsParent gptkb:Schistocytes
gptkbp:bfsLayer 8