Statements (57)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Atom
|
| gptkbp:associated_with |
chronic pain
pain sensation fibromyalgia chronic cough migraine cough reflex cardiovascular responses neurogenic inflammation |
| gptkbp:community |
cytokines
hormones neurotransmitters oxidative stress lipid mediators endocannabinoids |
| gptkbp:function |
detects environmental irritants
|
| https://www.w3.org/2000/01/rdf-schema#label |
TRPA1
|
| gptkbp:influences |
thermoregulation
pain perception sensory processing vascular permeability itch sensation neurogenic inflammation nociceptive signaling |
| gptkbp:initiated_by |
gptkb:ISKCON
gptkb:acrolein gptkb:formaldehyde gptkb:cinnamaldehyde cold temperatures menthol capsaicin certain anesthetics sodium channel blockers |
| gptkbp:interacts_with |
calcium ions
|
| gptkbp:involved_in |
pain pathways
nociception pain modulation allergic responses chemical nociception chemical sensitivity neurogenic edema pain threshold regulation respiratory reflexes thermoreception |
| gptkbp:is_expressed_in |
sensory neurons
skin cells lung tissue |
| gptkbp:is_linked_to |
gptkb:asthma
gptkb:neurodegenerative_diseases gastrointestinal disorders diabetes complications chronic inflammatory diseases |
| gptkbp:location |
cell membrane
|
| gptkbp:promoter |
gptkb:TRPA1_gene
|
| gptkbp:role |
inflammatory pain
|
| gptkbp:bfsParent |
gptkb:David_Julius
|
| gptkbp:bfsLayer |
5
|