Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
migraines
fibromyalgia pain perception osteoarthritis chronic pain conditions neuropathic pain diabetes-related pain |
| gptkbp:code |
TRPA1 protein
|
| gptkbp:discovered_by |
gptkb:David_Julius
|
| gptkbp:first_characterized_in |
gptkb:2000
|
| gptkbp:function |
detects environmental irritants
|
| gptkbp:genetic_studies |
hypersensitivity to pain
|
| gptkbp:has_role |
neurogenic inflammation
|
| https://www.w3.org/2000/01/rdf-schema#label |
TRPA1 gene
|
| gptkbp:influences |
neuronal excitability
|
| gptkbp:inhibitors_include |
HC-030031
|
| gptkbp:initiated_by |
cold temperatures
|
| gptkbp:interacts_with |
calcium ions
|
| gptkbp:involved_in |
gptkb:asthma
gptkb:neurodegenerative_diseases metabolic syndrome neuroscience research biomedical research pharmacogenomics chronic cough molecular biology research respiratory diseases pain management strategies pain research cough reflex nociception pain modulation cancer pain cardiovascular responses allergic responses chemical nociception itch sensation pain signaling pathways clinical studies of pain genetic studies of pain pain signaling research therapeutic drug development therapeutic targets for pain relief thermosensation |
| gptkbp:is_expressed_in |
gptkb:Skin
gastrointestinal tract sensory neurons lung tissue |
| gptkbp:located_in |
human chromosome 8
|
| gptkbp:related_to |
inflammatory responses
|
| gptkbp:bfsParent |
gptkb:TRPA1
|
| gptkbp:bfsLayer |
6
|