Statements (55)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:XPB_helicase
gptkb:XPD_helicase |
| gptkbp:associated_with |
gptkb:Cockayne_syndrome
Xeroderma pigmentosum |
| gptkbp:composed_of |
gptkb:XPB_helicase
gptkb:XPD_helicase gptkb:p44_subunit gptkb:p62_subunit CD K7 kinase cyclin H |
| gptkbp:discovered_by |
gptkb:Yoshinori_Watanabe
1990s |
| gptkbp:established |
chemical agents
UV radiation |
| gptkbp:function |
DNA repair
transcription initiation |
| gptkbp:genetic_diversity |
increased cancer risk
neurodegeneration photosensitivity growth defects |
| https://www.w3.org/2000/01/rdf-schema#label |
TFIIH complex
|
| gptkbp:interacts_with |
gptkb:RNA_polymerase_II
gptkb:TFIIE TFIIF TFIIA |
| gptkbp:is_involved_in |
nucleotide excision repair
transcription-coupled repair |
| gptkbp:location |
gptkb:physicist
|
| gptkbp:related_to |
DNA replication
DNA damage response cell cycle regulation cell differentiation cellular stress response chromatin remodeling immune response signal transduction stem cell biology cancer biology cellular aging genomic stability developmental biology DNA methylation gene expression regulation histone modification RNA processing therapeutic targets protein-protein interactions transcription elongation epigenetic regulation m RNA splicing |
| gptkbp:role |
unwinding DNA
recruitment of repair factors phosphorylation of RNA polymerase II |