Small Cell Carcinoma

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:cancer
Neuroendocrine Tumor
gptkbp:alsoKnownAs gptkb:Oat_Cell_Carcinoma
gptkbp:associatedWith Smoking
gptkbp:canMetastasizeTo gptkb:bone
gptkb:Brain
Liver
Adrenal Glands
gptkbp:cause Paraneoplastic Syndromes
gptkbp:characterizedBy Early Metastasis
Rapid Growth
gptkbp:commonIn Males
Older Adults
gptkbp:diagnosedBy Biopsy
Immunohistochemistry
gptkbp:differentialDiagnosis Lymphoma
Carcinoid Tumor
Non-Small Cell Lung Carcinoma
gptkbp:firstDescribed 1926
gptkbp:hasGeneticAlteration RB1 Mutation
TP53 Mutation
gptkbp:histology gptkb:Small_Round_Blue_Cells
Necrosis
High Mitotic Rate
https://www.w3.org/2000/01/rdf-schema#label Small Cell Carcinoma
gptkbp:ICD-10_code C34.1
gptkbp:incidence 15% of Lung Cancers
gptkbp:location Lung
gptkbp:marking gptkb:CD56
gptkb:Chromogranin_A
gptkb:Neuron-Specific_Enolase
gptkb:Synaptophysin
gptkbp:notTreatedWith Surgery (in most cases)
gptkbp:occurredIn Bladder
Cervix
Prostate
Gastrointestinal Tract
gptkbp:paraneoplasticSyndrome gptkb:Cushing_Syndrome
gptkb:Lambert-Eaton_Myasthenic_Syndrome
gptkb:SIADH
gptkbp:prognosis Poor
gptkbp:stagedBy Extensive Stage
Limited Stage
gptkbp:subspecies gptkb:Small_Cell_Lung_Carcinoma
Extrapulmonary Small Cell Carcinoma
gptkbp:treatment Radiation Therapy
immunotherapy
Chemotherapy
gptkbp:bfsParent gptkb:Oat_Cell_Carcinoma
gptkbp:bfsLayer 6