|
gptkbp:instance_of
|
gptkb:pharmaceuticals
|
|
gptkbp:approves
|
gptkb:1997
gptkb:European_Union
gptkb:United_States
|
|
gptkbp:atccode
|
A08 AA10
|
|
gptkbp:casnumber
|
84485-00-7
|
|
gptkbp:chemical_formula
|
C17 H26 Cl N
|
|
gptkbp:clinical_trial
|
metabolic syndrome
diabetes management
hypertension management
obesity treatment
bariatric surgery adjunct
|
|
gptkbp:contraindication
|
gptkb:anorexia_nervosa
gptkb:bulimia_nervosa
pregnancy
breastfeeding
history of cardiovascular disease
|
|
gptkbp:developed_by
|
gptkb:Abbott_Laboratories
|
|
gptkbp:discontinued
|
gptkb:Australia
gptkb:Canada
gptkb:European_Union
gptkb:New_Zealand
gptkb:United_Kingdom
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:formulation
|
oral tablet
oral capsule
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Sibutramine
|
|
gptkbp:interacts_with
|
antidepressants
MAO inhibitors
other weight loss medications
|
|
gptkbp:legal_status
|
prescription only
|
|
gptkbp:lifespan
|
14 hours
|
|
gptkbp:marketed_as
|
gptkb:Reductil
gptkb:Sibutrex
gptkb:Meridia
|
|
gptkbp:mechanism_of_action
|
gptkb:depression
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:replaces
|
several countries
|
|
gptkbp:side_effect
|
headache
nausea
hypertension
insomnia
constipation
dry mouth
increased heart rate
|
|
gptkbp:used_for
|
weight loss
|
|
gptkbp:bfsParent
|
gptkb:Meridia
|
|
gptkbp:bfsLayer
|
5
|