Statements (57)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:neurodegenerative_diseases
autophagy |
| gptkbp:code |
sequestosome 1 protein
|
| gptkbp:discovered_by |
gptkb:1997
|
| gptkbp:has_disease_association |
gptkb:frontotemporal_dementia
gptkb:Paget's_disease_of_bone |
| gptkbp:has_function |
scaffolding protein
|
| gptkbp:has_role |
immune response
protein degradation cellular signaling protein aggregation |
| gptkbp:has_variants |
A170 T
P392 L Q375 X R218 W R429 C |
| https://www.w3.org/2000/01/rdf-schema#label |
SQSTM1
|
| gptkbp:interacts_with |
ubiquitin
|
| gptkbp:involved_in |
cell signaling
NF-k B signaling pathway |
| gptkbp:is_expressed_in |
gptkb:sports_car
gptkb:Brain liver |
| gptkbp:is_involved_in |
metabolism
apoptosis cell cycle regulation cellular homeostasis protein synthesis signal transduction neuroinflammation cell survival oxidative stress response cellular aging cellular differentiation cellular repair mechanisms protein homeostasis stress granule formation |
| gptkbp:is_linked_to |
gptkb:Oncology
|
| gptkbp:is_part_of |
cellular stress response
autophagosome |
| gptkbp:is_regulated_by |
m TOR pathway
AMPK pathway p62 pathway |
| gptkbp:is_studied_in |
cancer research
autophagy research neurodegenerative research |
| gptkbp:located_in |
human chromosome 5
|
| gptkbp:orthologs |
SQSTM1 in mice
SQSTM1 in rats SQSTM1 in zebrafish |
| gptkbp:research |
protein binding
ubiquitin binding zinc ion binding |
| gptkbp:targets |
therapeutic drugs
|
| gptkbp:bfsParent |
gptkb:p62_subunit
|
| gptkbp:bfsLayer |
7
|