|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:pheochromocytoma
gptkb:hereditary_paraganglioma-pheochromocytoma_syndrome
paraganglioma
renal cell carcinoma
|
|
gptkbp:biologicalProcess
|
binds iron-sulfur clusters
transfers electrons from succinate to ubiquinone
|
|
gptkbp:clinicalTrialPhase
|
genetic testing available
|
|
gptkbp:discoveredBy
|
1990s
|
|
gptkbp:encodes
|
gptkb:succinate_dehydrogenase_iron-sulfur_subunit
|
|
gptkbp:Entrez_Gene_ID
|
6390
|
|
gptkbp:expressedIn
|
mitochondria
|
|
gptkbp:fullName
|
gptkb:succinate_dehydrogenase_complex_iron_sulfur_subunit_B
|
|
gptkbp:function
|
catalyzes oxidation of succinate to fumarate
component of mitochondrial complex II
involved in electron transport chain
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:10680
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SDHB gene
|
|
gptkbp:inheritance
|
autosomal dominant
|
|
gptkbp:length
|
280 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p36.13
chromosome 1
|
|
gptkbp:mutationAssociatedWith
|
increased risk of tumors
|
|
gptkbp:OMIM
|
185470
|
|
gptkbp:orthologInMouse
|
Sdhb
|
|
gptkbp:orthologInYeast
|
gptkb:SDH2
|
|
gptkbp:relatedTo
|
succinate dehydrogenase family
|
|
gptkbp:UniProtID
|
gptkb:P21912
|
|
gptkbp:bfsParent
|
gptkb:hereditary_paraganglioma-pheochromocytoma_syndromes
gptkb:succinate-coenzyme_Q_reductase
|
|
gptkbp:bfsLayer
|
7
|