Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:Oncology
|
| gptkbp:can_be_inactivated_by |
Tumor suppressor genes
|
| gptkbp:can_lead_to |
Tumor formation
|
| gptkbp:can_mutate_to |
gptkb:Oncogene
|
| gptkbp:discovered_by |
gptkb:Dr._J._Michael_Bishop
gptkb:Harold_Varmus |
| gptkbp:discovery_year |
1970s
|
| gptkbp:example |
gptkb:HER2
SRC MYC RAS |
| gptkbp:function |
Regulates cell growth
|
| https://www.w3.org/2000/01/rdf-schema#label |
Proto-Oncogene
|
| gptkbp:initiated_by |
Mutations
Chromosomal translocation Viral integration |
| gptkbp:involved_in |
Cell signaling pathways
|
| gptkbp:is_essential_for |
Normal cell function
|
| gptkbp:is_found_in |
Eukaryotic cells
Prokaryotic cells |
| gptkbp:is_involved_in |
Cell differentiation
Immune response Apoptosis regulation Cell migration Cellular metabolism Developmental processes Cellular communication Neurogenesis Cell survival Cellular response to stress Cell adhesion Stem cell maintenance Cellular homeostasis Tissue repair Metabolic regulation Hormonal signaling Cellular differentiation Cellular repair mechanisms Cellular aging Cellular adaptation |
| gptkbp:is_linked_to |
Metastasis
Angiogenesis Cell proliferation |
| gptkbp:is_part_of |
Signal transduction pathways
|
| gptkbp:is_regulated_by |
Transcription factors
Micro RNAs |
| gptkbp:is_studied_in |
Cancer research
|
| gptkbp:is_targeted_at |
Cancer therapies
|
| gptkbp:located_in |
gptkb:Atom
|
| gptkbp:role |
Cell cycle regulation
|
| gptkbp:bfsParent |
gptkb:Oncogene
|
| gptkbp:bfsLayer |
6
|