Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:affects |
gptkb:temperature
mutations pH solvent conditions |
| gptkbp:defines |
process by which a protein structure assumes its functional shape or conformation
|
| gptkbp:energyLandscape |
folding funnel
|
| gptkbp:field |
biochemistry
molecular biology |
| gptkbp:firstDescribed |
gptkb:Christian_B._Anfinsen
|
| https://www.w3.org/2000/01/rdf-schema#label |
Protein folding
|
| gptkbp:importantFor |
determines protein function
|
| gptkbp:NobelPrizeYear |
1972 Chemistry
|
| gptkbp:relatedTo |
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease gptkb:protein gptkb:van_der_Waals_forces gptkb:Ramachandran_plot protein aggregation protein misfolding denaturation electrostatic interactions disulfide bonds hydrogen bonding prion diseases protein homeostasis chaperone proteins secondary structure molecular chaperones tertiary structure hydrophobic effect unfoldase Levinthal's paradox amyloid fibrils foldase folding intermediates folding pathway molten globule protein folding diseases quaternary structure |
| gptkbp:result |
native structure
|
| gptkbp:studiedBy |
gptkb:AlphaFold
X-ray crystallography computational biology NMR spectroscopy cryo-electron microscopy |
| gptkbp:suffersFrom |
misfolding
|
| gptkbp:timescale |
microseconds to seconds
|
| gptkbp:bfsParent |
gptkb:Glycoproteins
|
| gptkbp:bfsLayer |
6
|