Protein Tyrosine Phosphatase

URI: https://gptkb.org/entity/Protein_Tyrosine_Phosphatase
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:activeSiteResidue cysteine
gptkbp:biologicalProcess phosphoprotein phosphatase activity
gptkbp:catalyzes removal of phosphate group from tyrosine residue
gptkbp:cofactor none required
gptkbp:discoveredBy gptkb:Edwin_G._Krebs
gptkb:Edmond_H._Fischer
gptkbp:EC_number 3.1.3.48
gptkbp:encodedBy gptkb:PTP_gene_family
gptkbp:foundIn eukaryotes
gptkbp:hasGOFunction gptkb:GO:0004725
gptkbp:inhibitedBy pervanadate
vanadate
gptkbp:involvedIn gptkb:diabetes
gptkb:immune_response
signal transduction
autoimmune diseases
oncogenesis
gptkbp:PDB gptkb:1PTY
gptkb:2HNQ
gptkbp:regulates cell differentiation
metabolism
cell growth
cell signaling
cell cycle
gptkbp:relatedTo gptkb:protein
gptkbp:subclassOf non-receptor protein tyrosine phosphatase
receptor-type protein tyrosine phosphatase
gptkbp:substrate phosphotyrosine-containing proteins
gptkbp:bfsParent gptkb:PTP
gptkbp:bfsLayer 5
https://www.w3.org/2000/01/rdf-schema#label Protein Tyrosine Phosphatase