|
gptkbp:instanceOf
|
gptkb:drug
ACE inhibitor
|
|
gptkbp:approvedBy
|
1988
|
|
gptkbp:ATCCode
|
C09AA04
|
|
gptkbp:availableOn
|
gptkb:tablet
oral solution
|
|
gptkbp:brand
|
Aceon
Coversum
Coversyl
|
|
gptkbp:CASNumber
|
82834-16-0
|
|
gptkbp:category
|
prodrug
antihypertensive agent
carboxamide
pyrrolidine derivative
|
|
gptkbp:chemicalFormula
|
C19H32N2O5
|
|
gptkbp:contraindication
|
pregnancy
history of angioedema
|
|
gptkbp:discoveredBy
|
gptkb:Servier_Laboratories
|
|
gptkbp:drugClass
|
ACE inhibitor
|
|
gptkbp:eliminationHalfLife
|
1 hour (perindopril), 3-10 hours (perindoprilat)
|
|
gptkbp:excretion
|
urine
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Perindopril
|
|
gptkbp:interactsWith
|
gptkb:NSAIDs
gptkb:aliskiren
lithium
potassium-sparing diuretics
other antihypertensives
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits angiotensin-converting enzyme
|
|
gptkbp:metabolism
|
perindoprilat
|
|
gptkbp:pregnancyCategory
|
gptkb:D_(Australia)
D (US)
|
|
gptkbp:proteinBinding
|
20%
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
dizziness
cough
hypotension
renal impairment
hyperkalemia
|
|
gptkbp:synonym
|
Perindopril arginine
Perindopril erbumine
|
|
gptkbp:usedFor
|
heart failure
hypertension
prevention of cardiovascular events
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Servier
gptkb:Servier_Pharmaceuticals
gptkb:Servier_Laboratories
|
|
gptkbp:bfsLayer
|
7
|