Peptidylglycine alpha-amidating monooxygenase

URI: https://gptkb.org/entity/Peptidylglycine_alpha-amidating_monooxygenase
GPTKB entity
Statements (31)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:abbreviation gptkb:PAM
gptkbp:alternativeSplicing produces multiple isoforms
gptkbp:associatedWith neuroendocrine disorders
gptkbp:cofactor copper
ascorbate
gptkbp:discoveredBy 1980s
gptkbp:domain gptkb:peptidylglycine_alpha-hydroxylating_monooxygenase_domain
peptidyl-alpha-hydroxyglycine alpha-amidating lyase domain
gptkbp:EC_number 1.14.17.3
gptkbp:foundIn gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:function catalyzes the conversion of peptidylglycine substrates to peptidyl-amides
gptkbp:gene gptkb:PAM
gptkbp:GO_term gptkb:GO:0004504
https://www.w3.org/2000/01/rdf-schema#label Peptidylglycine alpha-amidating monooxygenase
gptkbp:locatedOnChromosome chromosome 5q21
gptkbp:location gptkb:Golgi_apparatus
secretory granules
gptkbp:OMIM 170270
gptkbp:product glyoxylate
peptidyl-amide
gptkbp:requires molecular oxygen
peptide hormone maturation
ascorbate
copper ion
gptkbp:structure bifunctional enzyme
gptkbp:substrate peptidylglycine
gptkbp:UniProtID gptkb:P19021
gptkbp:bfsParent gptkb:PAM
gptkbp:bfsLayer 7