Statements (43)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:alsoKnownAs |
gptkb:hexose_monophosphate_shunt
gptkb:phosphogluconate_pathway |
| gptkbp:deficiencyCauses |
gptkb:anemia
glucose-6-phosphate dehydrogenase deficiency |
| gptkbp:discoveredBy |
gptkb:Otto_Warburg
|
| gptkbp:discoveredIn |
1930s
|
| gptkbp:foundIn |
prokaryotes
eukaryotes |
| https://www.w3.org/2000/01/rdf-schema#label |
Pentose phosphate pathway
|
| gptkbp:importantFor |
biosynthesis of fatty acids
protection against oxidative stress biosynthesis of nucleotides |
| gptkbp:keyEnzyme |
gptkb:glucose-6-phosphate_dehydrogenase
gptkb:6-phosphogluconolactonase gptkb:transketolase gptkb:6-phosphogluconate_dehydrogenase gptkb:transaldolase |
| gptkbp:mainFunction |
generate NADPH
produce ribose-5-phosphate provide intermediates for nucleotide synthesis |
| gptkbp:occurredIn |
gptkb:cytoplasm
|
| gptkbp:period |
non-oxidative phase
oxidative phase |
| gptkbp:product |
CO2
NADPH glyceraldehyde-3-phosphate erythrose-4-phosphate fructose-6-phosphate ribose-5-phosphate sedoheptulose-7-phosphate xylulose-5-phosphate |
| gptkbp:provides |
precursors for nucleotide synthesis
reducing power for biosynthetic reactions |
| gptkbp:regulates |
glucose-6-phosphate dehydrogenase activity
NADP+ concentration |
| gptkbp:relatedTo |
glycolysis
gluconeogenesis |
| gptkbp:requires |
antioxidant defense
red blood cell function |
| gptkbp:substrate |
gptkb:glucose-6-phosphate
|
| gptkbp:bfsParent |
gptkb:Meyerhof-Parnas_pathway
|
| gptkbp:bfsLayer |
6
|