Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeName |
PKG1
PRKGR1A PRKGR1B cGK cGKI |
| gptkbp:associatedWith |
hypertension
erectile dysfunction thoracic aortic aneurysm and dissection |
| gptkbp:biologicalProcess |
signal transduction
synaptic transmission ATP binding protein kinase activity regulation of blood pressure smooth muscle contraction cGMP binding |
| gptkbp:cellularComponent |
gptkb:nucleus
gptkb:cytoplasm gptkb:plasma_membrane |
| gptkbp:encodes |
cGMP-dependent protein kinase 1
|
| gptkbp:Entrez_Gene_ID |
5592
ENSG00000185532 |
| gptkbp:expressedIn |
brain
platelets smooth muscle |
| gptkbp:fullName |
protein kinase, cGMP-dependent, type I
|
| gptkbp:function |
involved in neuronal signaling
involved in platelet function mediates the effects of cGMP in cells regulates smooth muscle relaxation |
| gptkbp:hasIsoform |
PRKG1 alpha
PRKG1 beta |
| gptkbp:HGNC_ID |
HGNC:9406
|
| https://www.w3.org/2000/01/rdf-schema#label |
PRKG1
|
| gptkbp:locatedOnChromosome |
10q11.23
|
| gptkbp:OMIM |
176894
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Prkg1
|
| gptkbp:PDB |
4KU7
4Z07 5BV6 |
| gptkbp:postTranslationalModification |
phosphorylation
autophosphorylation |
| gptkbp:proteinFamily |
serine/threonine protein kinases
|
| gptkbp:RefSeq |
NM_006258
|
| gptkbp:regulates |
activated by cGMP
inhibited by PKI |
| gptkbp:UniProtID |
Q13976
|
| gptkbp:bfsParent |
gptkb:chromosome_10
|
| gptkbp:bfsLayer |
6
|