Statements (32)
Predicate | Object |
---|---|
gptkbp:instanceOf |
gptkb:drug
small molecule |
gptkbp:administeredBy |
oral
|
gptkbp:approvalYear |
2011
|
gptkbp:approvedBy |
gptkb:FDA
metastatic melanoma |
gptkbp:ATCCode |
L01EC01
|
gptkbp:brand |
gptkb:Zelboraf
|
gptkbp:CASNumber |
918504-65-1
|
gptkbp:chemicalFormula |
C23H18ClF2N3O3S
|
gptkbp:clinicalTrialPhase |
Phase III
|
gptkbp:combines |
gptkb:cobimetinib
|
gptkbp:contraindication |
pregnancy
QT prolongation |
gptkbp:developedBy |
gptkb:Plexxikon
gptkb:Roche |
gptkbp:discoveredIn |
2005
|
gptkbp:eliminationHalfLife |
57 hours
|
https://www.w3.org/2000/01/rdf-schema#label |
PLX4032
|
gptkbp:indication |
gptkb:BRAF_V600E-positive_melanoma
unresectable melanoma |
gptkbp:mechanismOfAction |
BRAF inhibitor
|
gptkbp:metabolism |
gptkb:CYP3A4
|
gptkbp:sideEffect |
gptkb:cutaneous_squamous_cell_carcinoma
fatigue rash photosensitivity arthralgia |
gptkbp:synonym |
gptkb:vemurafenib
|
gptkbp:target |
gptkb:BRAF_V600E_mutation
|
gptkbp:bfsParent |
gptkb:vemurafenib
|
gptkbp:bfsLayer |
6
|