|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:CD31
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:antibodyTarget
|
yes
|
|
gptkbp:cellSurfaceMarker
|
yes
|
|
gptkbp:cytoplasmicDomain
|
contains ITIM motifs
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:encodedBy
|
PECAM1 gene
|
|
gptkbp:expressedIn
|
hematopoietic cells
vascular endothelium
|
|
gptkbp:extracellularDomains
|
6 Ig-like domains
|
|
gptkbp:foundIn
|
gptkb:leukocytes
platelets
endothelial cells
|
|
gptkbp:function
|
signal transduction
angiogenesis
cell adhesion
leukocyte transmigration
|
|
gptkbp:gene
|
PECAM1
|
|
gptkbp:glycosylation
|
yes
|
|
gptkbp:heterophilicBinding
|
yes
|
|
gptkbp:HGNC_ID
|
HGNC:8823
|
|
gptkbp:homophilicBinding
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PECAM-1
|
|
gptkbp:interactsWith
|
gptkb:CD38
gptkb:VE-cadherin
SH2 domain-containing proteins
|
|
gptkbp:involvedIn
|
inflammation
immune response
|
|
gptkbp:length
|
738 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
|
|
gptkbp:marking
|
endothelial cells
|
|
gptkbp:molecularWeight
|
130 kDa
|
|
gptkbp:OMIM
|
173445
|
|
gptkbp:PDB
|
1NV7
|
|
gptkbp:phosphorylates
|
tyrosine residues
|
|
gptkbp:regulates
|
leukocyte migration
vascular permeability
angiogenic signaling
|
|
gptkbp:role
|
atherosclerosis
inflammatory diseases
cancer metastasis
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:structure
|
gptkb:immunoglobulin_superfamily
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
cell junctions
|
|
gptkbp:UniProtID
|
P16284
|
|
gptkbp:bfsParent
|
gptkb:immunoglobulin_superfamily
|
|
gptkbp:bfsLayer
|
7
|