Statements (57)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
UniProt accession number
|
| gptkbp:activeSiteResidue |
Asp102
His57 Ser195 |
| gptkbp:alternativeName |
ELT
ELA2 ELANE_HUMAN Elastase, neutrophil expressed HNE Leukocyte elastase Medullasin Serine protease 4 Serine protease, neutrophil |
| gptkbp:associatedWith |
Cyclic neutropenia
Severe congenital neutropenia |
| gptkbp:catalyzes |
Hydrolysis of proteins, including elastin
|
| gptkbp:citation |
Ensembl:ENSG00000197561
GeneCards:ELANE KEGG:hsa:1991 Reactome:R-HSA-6798695 |
| gptkbp:Entrez_Gene_ID |
1991
|
| gptkbp:enzymeCommissionNumber |
3.4.21.37
|
| gptkbp:expressedIn |
gptkb:Blood
gptkb:Bone_marrow |
| gptkbp:family |
Peptidase S1 family
|
| gptkbp:function |
serine protease involved in degradation of proteins
|
| gptkbp:gene |
gptkb:ELANE
|
| gptkbp:HGNC_ID |
HGNC:3327
|
| https://www.w3.org/2000/01/rdf-schema#label |
P08247
|
| gptkbp:inhibitedBy |
Alpha-1-antitrypsin
Elafin SLPI |
| gptkbp:locatedOnChromosome |
gptkb:19p13.3
|
| gptkbp:molecularWeight |
29 kDa
|
| gptkbp:OMIM |
130130
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:pathway |
Innate Immune System
Neutrophil degranulation |
| gptkbp:PDB |
1HNE
1PPF 3Q76 4WNO 5A7N 6QF7 |
| gptkbp:postTranslationalModification |
Phosphorylation
Glycosylation |
| gptkbp:protein_name |
Neutrophil elastase
|
| gptkbp:refersTo |
human elastase-2
|
| gptkbp:RefSeq |
NP_001965.1
|
| gptkbp:sequence |
267
|
| gptkbp:sequenceStatus |
Reviewed
|
| gptkbp:subcellularLocation |
Secreted
Azurophil granule |
| gptkbp:tissue_specificity |
Neutrophils
|
| gptkbp:UniGene |
Hs.654
|
| gptkbp:bfsParent |
gptkb:Synaptophysin
|
| gptkbp:bfsLayer |
6
|