Statements (39)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
gptkb:NF-κB_pathway
NLRP3 inflammasome |
| gptkbp:alternativeName |
NS3 protein
U274 protein |
| gptkbp:encodedBy |
gptkb:COVID-19
|
| gptkbp:firstDescribed |
2003
|
| gptkbp:function |
induces apoptosis
ion channel activity modulates host immune response viroporin |
| https://www.w3.org/2000/01/rdf-schema#label |
ORF3a protein
|
| gptkbp:inducedBy |
pro-inflammatory cytokines
apoptosis in host cells |
| gptkbp:interactsWith |
host NLRP3 inflammasome
host TRAF3 host caveolin-1 |
| gptkbp:involvedIn |
virus pathogenesis
host cell death virus release |
| gptkbp:involves |
COVID-19 pathogenesis
host immune evasion |
| gptkbp:length |
275 amino acids
|
| gptkbp:locale |
gptkb:endoplasmic_reticulum
gptkb:Golgi_apparatus gptkb:plasma_membrane |
| gptkbp:locatedOnChromosome |
ORF3a gene
|
| gptkbp:molecularWeight |
31 kDa
|
| gptkbp:postTranslationalModification |
glycosylation
ubiquitination |
| gptkbp:presentIn |
gptkb:COVID-19
gptkb:SARS-CoV bat SARS-like coronaviruses |
| gptkbp:sequenceSimilarity |
SARS-CoV ORF3a protein
bat coronavirus ORF3a protein |
| gptkbp:structure |
transmembrane protein
contains three transmembrane domains |
| gptkbp:bfsParent |
gptkb:SARS-CoV-2_virion
|
| gptkbp:bfsLayer |
7
|