Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:monoclonal_antibody
immunosuppressant |
| gptkbp:approvedBy |
gptkb:FDA
1986 |
| gptkbp:ATCCode |
L04AA01
|
| gptkbp:brand |
Orthoclone OKT3
|
| gptkbp:CASNumber |
130948-15-5
|
| gptkbp:developer |
Ortho Biotech
|
| https://www.w3.org/2000/01/rdf-schema#label |
muromonab-CD3
|
| gptkbp:immunoglobulinType |
gptkb:IgG2a
|
| gptkbp:indication |
acute cardiac transplant rejection
acute hepatic transplant rejection acute renal transplant rejection |
| gptkbp:legalStatus |
withdrawn
|
| gptkbp:macromoleculeType |
gptkb:T_cell_receptor_complex
|
| gptkbp:mechanismOfAction |
depletes T cells
|
| gptkbp:monoclonalAntibodyType |
murine
|
| gptkbp:origin |
gptkb:mouse
|
| gptkbp:routeOfAdministration |
intravenous
|
| gptkbp:sideEffect |
fever
nausea headache chills cytokine release syndrome increased risk of infection |
| gptkbp:target |
CD3 receptor
|
| gptkbp:UNII |
6F4YY77TQF
|
| gptkbp:usedFor |
prevention of organ transplant rejection
|
| gptkbp:withdrawn |
2010
|
| gptkbp:bfsParent |
gptkb:anti-CD3_antibody
|
| gptkbp:bfsLayer |
7
|