Statements (57)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
complex
|
| gptkbp:hasFunction |
synthesizing 2',5'-oligoadenylates
|
| gptkbp:hasProductLine |
OAS1
OAS2 |
| gptkbp:hasRole |
cellular defense mechanisms
|
| https://www.w3.org/2000/01/rdf-schema#label |
OAS complex
|
| gptkbp:isActiveIn |
viral RNA
|
| gptkbp:isAssociatedWith |
neurodegenerative diseases
autoimmune diseases chronic inflammation viral pathogenesis chronic viral infections |
| gptkbp:isCharacterizedBy |
dimerization
enzyme activity. oligoadenylate synthesis |
| gptkbp:isCounteredBy |
enzyme assays
small molecules antiviral drugs viral proteins |
| gptkbp:isDividedInto |
inflammatory stimuli
|
| gptkbp:isFoundIn |
human cells
|
| gptkbp:isInfluencedBy |
cellular stress signals
|
| gptkbp:isIntegratedWith |
RNase L
|
| gptkbp:isInvolvedIn |
apoptosis regulation
signal transduction immune cell activation cellular signaling pathways cytokine production protein synthesis regulation cellular apoptosis pathways antiviral response mRNA decay |
| gptkbp:isLinkedTo |
viral infections
host-pathogen interactions tumor progression immune evasion strategies |
| gptkbp:isLocatedIn |
various tissues
immune responses viral infections |
| gptkbp:isPartOf |
innate immune system
immune response pathways RNA interference pathways antiviral signaling networks host defense mechanisms |
| gptkbp:isRegulatedBy |
transcription factors
cytokines |
| gptkbp:isRelatedTo |
interferon signaling
|
| gptkbp:isStudiedIn |
therapeutic interventions
cancer research diagnostic purposes vaccine development |
| gptkbp:isTrainedIn |
therapeutic agents
|
| gptkbp:isUtilizedFor |
RNA degradation
|
| gptkbp:isVisitedBy |
pathogen-associated molecular patterns (PAMPs)
cellular signaling molecules double-stranded RNA viral replication intermediates |