Nucleotide Excision Repair

URI: https://gptkb.org/entity/Nucleotide_Excision_Repair
GPTKB entity
Statements (45)
Predicate Object
gptkbp:instanceOf DNA repair mechanism
gptkbp:abbreviation NER
gptkbp:defectCauses gptkb:Cockayne_syndrome
gptkb:trichothiodystrophy
gptkb:xeroderma_pigmentosum
gptkbp:firstDescribed 1970s
gptkbp:foundIn prokaryotes
eukaryotes
https://www.w3.org/2000/01/rdf-schema#label Nucleotide Excision Repair
gptkbp:involves DNA synthesis
DNA ligation
DNA unwinding
damage recognition
dual incision
excision of oligonucleotide
gptkbp:keyProtein gptkb:XPC
gptkb:XPA
gptkb:ERCC1
gptkb:XPD
gptkb:XPG
gptkb:CSA
gptkb:CSB
XPF
XPB
gptkbp:prevention mutagenesis
carcinogenesis
gptkbp:processor multistep
gptkbp:regulates transcription
cell cycle
gptkbp:relatedTo base excision repair
mismatch repair
gptkbp:removes 6-4 photoproducts
bulky DNA lesions
chemical adducts
pyrimidine dimers
gptkbp:repairs DNA damage
gptkbp:requires gptkb:ATP
gptkb:DNA_ligase
DNA polymerase
gptkbp:studiedIn gptkb:Bacteria
human cells
gptkbp:subspecies global genome NER
transcription-coupled NER
gptkbp:bfsParent gptkb:Base_Excision_Repair
gptkbp:bfsLayer 7