|
gptkbp:instanceOf
|
gptkb:drug
opioid
|
|
gptkbp:approvedBy
|
gptkb:Japan
gptkb:United_States
gptkb:FDA
2017
|
|
gptkbp:ATCCode
|
gptkb:A06AH05
|
|
gptkbp:brand
|
gptkb:Symproic
|
|
gptkbp:CASNumber
|
916221-64-6
|
|
gptkbp:chemicalClass
|
naltrexone derivative
|
|
gptkbp:contraindication
|
known hypersensitivity
|
|
gptkbp:developedBy
|
gptkb:Shionogi
|
|
gptkbp:eliminationHalfLife
|
11 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:hasMolecularFormula
|
C32H34N4O6
|
|
gptkbp:hasSMILES
|
CC1=CC(=O)N(C2=CC=CC=C12)C3CCN(CC3)CC4=CC=C(C=C4)C(=O)N5CCN(CC5)C(=O)COC6=CC=CC=C6O
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Naldemedine
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
peripherally acting mu-opioid receptor antagonist
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
570.6 g/mol
|
|
gptkbp:pregnancyCategory
|
not assigned (US)
|
|
gptkbp:PubChem_CID
|
24964624
DB11861
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
vomiting
diarrhea
abdominal pain
gastroenteritis
|
|
gptkbp:UNII
|
6T6J2G089B
|
|
gptkbp:usedFor
|
opioid-induced constipation
|
|
gptkbp:bfsParent
|
gptkb:DB11363
|
|
gptkbp:bfsLayer
|
7
|